Sinefungin

• 产品号: S8559
• CAS号: 58944-73-3
• 分子式: C15H23N7O5
• 分子量: 381.38702
• 纯 度: 95% (HPLC)

产品别名

• 标题: Sinefungin
• IUPAC标准名: (2S,5S)-2,5-diamino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]hexanoic acid
• IUPAC传统名: sinefungin
• 别名: A-9145; Antibiotic 32232RP; 5′-Deoxy-5′-(1,4-diamino-4-carboxybutyl)adenosine; Adenosylornithine

产品登记号

• PubChem SID: 24899800
• CAS号: 58944-73-3

产品性质

• 纯度: 95% (HPLC)
• 外观: white to yellow powder
• 溶解度: H2O: soluble
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• 危险公开号: 22
• RTECS编号: HE3140000
• 安全公开号: 36
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Sinefungin blocks the methylation of bases in DNA and RNA, such as 5-methylcytosine or N6-methyladenosine, suggesting a role in gene expression. In addition, sinefugin is involved in physiological processes such as aging and carcinogenesis.
Sinefungin blocks the methylation of bases in DNA and RNA, such as 5-methylcytosine or N6-methyladenosine, suggesting a role in gene expression. In addition, sinefugin is involved in physiological processes such as aging and carcinogenesis.Methylation inhibition by sinefugin is often accompanied by an altered rate of cytosine deamination that is coupled to transition mutation in the DNA. Sinefugin inhibits Epstein-Barr viral activity and this inhibition is related to the change in DNA methylation and gene expression. It can cause a rate change in several restriction DNA endonuclease activities, including Mme I, which is not connected to the inhibition of the methytransferase activity.