S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt

• 产品号: A2408
• CAS号: 17176-17-9
• 分子式: C22H30N6O8S2
• 分子量: 570.639
• 纯 度: ≥80% (HPLC)

产品别名

• 标题: S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt
• IUPAC标准名: [(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium 4-methylbenzene-1-sulfonate
• IUPAC传统名: SAMe tosylate
• 别名: AdoMet; SAM p-toluenesulfonate salt

产品登记号

• CAS号: 17176-17-9
• MDL号: MFCD00063498
• PubChem SID: 24890653

产品性质

• 生物来源: from yeast (L-methionine enriched)
• 主要成分: p-Toluenesulfonate content, 1.6-4.4 mol/mol
• 纯度: ≥80% (HPLC)
• 纯度: ≥80% (spectrophotometric assay)
• 运输包装: dry ice
• 溶解度: H2O: soluble100 mg/mL
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
S-(5′-Adenosyl)-L-methionine (SAM) is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
Caution
This material is unstable at room temperature.