3,3′-Methylene-bis(4-hydroxycoumarin)

• 产品号: M1390
• CAS号: 66-76-2
• 分子式: C19H12O6
• 分子量: 336.29498

产品别名

• 标题: 3,3′-Methylene-bis(4-hydroxycoumarin)
• IUPAC标准名: 4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-2H-chromen-2-one
• IUPAC传统名: dicoumarol
• 别名: Dicoumarol; Dicumarol

产品登记号

• PubChem SID: 24896643
• MDL号: MFCD00006857
• EC号: 200-632-9
• CAS号: 66-76-2

产品性质

• 相关基因信息: human ... CYP2C9(1559)
• 熔点: 290-292 °C(lit.)
• GHS警示词: Danger
• GHS危险声明: H302-H372-H411
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• 个人保护装置: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS警示性声明: P273-P314
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 22-48/25-51/53
• RTECS编号: GN7875000
• 安全公开号: 37-45-61
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Prototype of the 4-hydroxycoumarin class of anticoagulants, which act as vitamin K antagonists, preventing formation of prothrombin. There are many reports that dicumarol also inhibits NADPH:quinone oxidoreductase (NQO(1)). In one1, it inhibited NQO(1) in a pancreatic cancer cell line, causing increased formation of superoxide and inhibiting cell growth.