Mitoxantrone dihydrochloride

• 产品号: M6545
• CAS号: 70476-82-3
• 分子式: C22H30Cl2N4O6
• 分子量: 517.4028
• 纯 度: ≥97% (HPLC)

产品别名

• 标题: Mitoxantrone dihydrochloride
• IUPAC标准名: 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-dihydroanthracene-9,10-dione dihydrochloride
• IUPAC传统名: mitoxantrone dihydrochloride
• 别名: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride

产品登记号

• PubChem SID: 24278562
• CAS号: 70476-82-3
• MDL号: MFCD00242943
• EC号: 274-619-1

产品性质

• 纯度: ≥97% (HPLC)
• GHS警示词: Danger
• GHS危险声明: H360
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P201-P308 + P313
• 危险公开号: 46-61
• RTECS编号: CB5748500
• 安全公开号: 53-36/37/39-45
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. It used clinically as a chemotherapeutic agent against leukemias and solid tumors and as an immune system modulator in multiple sclerosis.