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Econazole nitrate salt_分子结构_CAS_24169-02-6)
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Econazole nitrate salt

产品号 E4632 公司名称 Sigma Aldrich
CAS号 24169-02-6 公司网站 http://www.sigmaaldrich.com
分子式 C18H16Cl3N3O4 电 话 1-800-521-8956
分子量 444.69634 传 真
纯 度 电子邮件
保 存 Chembase数据库ID: 73070

产品价格信息

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产品别名

标题
Econazole nitrate salt
IUPAC标准名
1-{2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; nitric acid
IUPAC传统名
acid, nitric; econazole
别名
1-(2-[(4-Chlorophenyl)methoxy]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole

产品登记号

PubChem SID 24894567
MDL号 MFCD00058160
CAS号 24169-02-6
EC号 246-053-5

产品性质

GHS危险品标识 GHS07
GHS警示词 Warning
GHS危险声明 H302-H315-H319
欧盟危险性物质标志 有害性(Harmful) 有害性(Harmful) (Xn)
个人保护装置 dust mask type N95 (US), Eyeshields, Gloves
GHS警示性声明 P305 + P351 + P338
危险公开号 22-36/38
RTECS编号 NI4450000
安全公开号 26-36
德国WGK号 3

产品详细信息

详细说明 (English)
Application
Econazole is a broad spectrum antimycotic similar to ketoconazole. It has some action against Gram positive bacteria. It is used topically in dermatomycoses as well as orally and parenterally. It is used for studies on processes such as platelet serotonin uptake, prostanoid biosynthesis, EDHF-mediated relaxation, and Ca2+ transport pathways in thymic lymphocytes1.
Biochem/physiol Actions
Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis. It Inhibits Ca2+ transport pathways in thymic lymphocytes1.

参考文献