SKF-96365

• 产品号: S7809
• CAS号: 130495-35-1
• 分子式: C22H27ClN2O3
• 分子量: 402.91438
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: SKF-96365
• IUPAC标准名: 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]-1H-imidazole hydrochloride
• IUPAC传统名: 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole hydrochloride
• 别名: 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole; 1-[β-(3-(4-Methoxyphenyl)propoxy)-4-methoxyphenethyl]-1H-imidazole hydrochloride

产品登记号

• MDL号: MFCD00236407
• PubChem SID: 24278710
• CAS号: 130495-35-1

产品性质

• 纯度: ≥98% (HPLC)
• 外观: white solid
• 溶解度: DMSO: >20 mg/mL
• 溶解度: H2O: >20 mg/mL
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26-36
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
SKF-96365 is a selective inhibitor of receptor-mediated Ca2+ entry and voltage-gated Ca2+ entry. In circular smooth muscle bundles isolated from the guinea-pig stomach antrum, the effects of quinidine, Ni2+, flufenamic acid, niflumic acid, La3+, SKF-96365 and 4′-diisothiocyanatostilbene-2,2′-disulphonic acid (DIDS) on acetylcholine (ACh)-induced depolarization were investigated. SKF-96365 (3-50 μM) depolarized the membrane in a concentration-dependent manner, but did not change the level of ACh-induced depolarization. These results provide evidence that ACh-induced depolarization is not inhibited by chemicals known to inhibit non-selective cation channels.