您当前所在的位置:首页 > 产品中心 > 产品信息
Prostaglandin E2_分子结构_CAS_363-24-6)
点击图片或这里关闭

Prostaglandin E2

产品号 P5640 公司名称 Sigma Aldrich
CAS号 363-24-6 公司网站 http://www.sigmaaldrich.com
分子式 C20H32O5 电 话 1-800-521-8956
分子量 352.46508 传 真
纯 度 ≥93% (HPLC) 电子邮件
保 存 Chembase数据库ID: 793

产品价格信息

请登录

产品别名

标题
Prostaglandin E2
IUPAC标准名
(5Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoic acid
IUPAC传统名
dinoprostone
别名
(5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid
PGE2
Dinoprostone

产品登记号

MDL号 MFCD00077861
PubChem SID 24898683
CAS号 363-24-6
Beilstein号 4709356
EC号 206-656-6

产品性质

生物来源 synthetic
纯度 ≥93% (HPLC)
相关基因信息 human ... PTGER1(5731), PTGER2(5732), PTGER3(5733), PTGER4(5734), PTGIR(5739)mouse ... Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219)
GHS危险品标识 GHS07
GHS危险品标识 GHS08
GHS警示词 Danger
GHS危险声明 H302-H360
欧盟危险性物质标志 有毒(Toxic) 有毒(Toxic) (T)
个人保护装置 Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS警示性声明 P201-P308 + P313
危险公开号 60-61-22
RTECS编号 UK8000000
安全公开号 53-22-26-36/37/39-45
保存温度 -20°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Most biologically active prostaglandin. PGE2 induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE2-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.The effect of PGE2 on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.1

参考文献