Streptozocin

• 产品号: S0130
• CAS号: 18883-66-4
• 分子式: C8H15N3O7
• 分子量: 265.2206
• 纯 度: ≥75% α-anomer basis

产品别名

• 标题: Streptozocin
• IUPAC标准名: 3-methyl-3-nitroso-1-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
• IUPAC传统名: streptozocin
• 别名: Streptozotocin; N-(Methylnitrosocarbamoyl)-α-D-glucosamine

产品登记号

• PubChem SID: 24899428
• MDL号: MFCD00006607
• EC号: 242-646-8
• Beilstein号: 2060675
• CAS号: 18883-66-4

产品性质

• 纯度: ≥75% α-anomer basis
• 纯度: ≥98% (HPLC)
• 外观: white to off-white powder
• 熔点: 121 °C (dec.)(lit.)
• GHS警示词: Danger
• GHS危险声明: H350
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P201-P308 + P313
• 危险公开号: 45
• RTECS编号: LZ5775000
• 安全公开号: 53-45
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
Streptozocin is used to induce Type 1 diabetes for medical research.
General description
Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.
Other Notes
Mixed anomers
包装
1, 5 g in glass bottle
100, 500 mg in glass bottle
50 mg in poly bottle
Biochem/physiol Actions
An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage.1 Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.