Triptolide

• 产品号: T3652
• CAS号: 38748-32-2
• 分子式: C20H24O6
• 分子量: 360.40096
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Triptolide
• IUPAC标准名: (1S,2S,4S,5S,7R,8R,9S,11S)-8-hydroxy-1-methyl-7-(propan-2-yl)-3,6,10,16-tetraoxaheptacyclo[11.7.0.0^2,^4.0^2,^9.0^5,^7.0^9,^1^1.0^1^4,^1^8]icos-14(18)-en-17-one
• IUPAC传统名: (1S,2S,4S,5S,7R,8R,9S,11S)-8-hydroxy-7-isopropyl-1-methyl-3,6,10,16-tetraoxaheptacyclo[11.7.0.0^2,^4.0^2,^9.0^5,^7.0^9,^1^1.0^1^4,^1^8]icos-14(18)-en-17-one
• 别名: PG 490

产品登记号

• CAS号: 38748-32-2
• MDL号: MFCD00210565
• PubChem SID: 24900156

产品性质

• RTECS编号: YK7751000
• 保存温度: 2-8°C
• 德国WGK号: 3
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 生物来源: from Tripterygium wilfordii
• 纯度: ≥98% (HPLC)
• 外观: white to off-white solid
• 溶解度: DMSO: soluble

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Triptolide is a diterpene triepoxide, the principal active ingredient in extracts from the Chinese herb Tripterygium wilfordii hook (TwHF). It is a potent immunosuppressant and anti-inflammatory. Triptolide has been shown to inhibit the expression of IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-κB mediated transcription activation. It synergizes with cyclosporin A in promoting graft survival in animal models and in suppression of graft versus host disease in allogeneic bone marrow transplants. In addition, it induces apoptosis in tumor cells and potentiates tumor necrosis factor (TNFα) induction of apoptosis in part through the suppression of c-IAP2 and c-IAP1 induction.