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精胺_分子结构_CAS_71-44-3)
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精胺

产品号 S4264 公司名称 Sigma Aldrich
CAS号 71-44-3 公司网站 http://www.sigmaaldrich.com
分子式 C10H26N4 电 话 1-800-521-8956
分子量 202.34024 传 真
纯 度 ≥96% 电子邮件
保 存 Chembase数据库ID: 13

产品价格信息

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产品别名

标题
Spermine
IUPAC标准名
(3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amine
IUPAC传统名
spermine
别名
N,N′-双(3-氨基丙基)-1,4-丁二胺
精素
肌胺
肝胺

产品登记号

Beilstein号 1750791
CAS号 71-44-3
EC号 200-754-2
MDL号 MFCD00008215
PubChem SID 24899594

产品性质

纯度 ≥96%
适用性 suitable for cell culture
相关基因信息 human ... GRIN2B(2904)rat ... Grin2a(24409)
外观 amorphous semi-solid
沸点 150 °C/5 mmHg(lit.)
闪点 110 °C
闪点 230 °F
熔点 28-30(lit.)
溶解度 H2O: soluble50 mg/mL
GHS危险品标识 GHS05
GHS警示词 Danger
GHS危险声明 H314
欧盟危险性物质标志 腐蚀性(Corrosive) 腐蚀性(Corrosive) (C)
个人保护装置 Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS警示性声明 P280-P305 + P351 + P338-P310
RID/ADR UN 3259 8/PG 2
危险公开号 34
RTECS编号 EJ7175000
安全公开号 26-36/37/39-45
保存温度 2-8°C
联合国危险货物等级 8
联合国危险货物编号 3259
联合国危险货物包装类别(PG) 2
德国WGK号 3

产品详细信息

详细说明 (简体中文)
Biochem/physiol Actions
Spermine together with putrescine and spermidine compose a family of polyamines (polycations) that are required for the growth and survival of the vast majority of living cells. Polyamines interact with negatively charged molecules such as proteoglycans, glycated proteins and nucleic acids (DNA and RNA). Biogenic polyamines are found to modulate protein synthesis at different levels. This effect may be explained by the ability of polyamines to bind and influence the secondary structure of tRNA, mRNA, and rRNA. Spermine also helps stabilize nucleic acid helical structure and the conformation of glycated proteins such as the histones. Spermine and spermidine are components of various nucleic acid transfection protocols.Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
多胺位点混合型 NMDA 谷氨酸受体激动剂/拮抗剂。在高浓度 (1mM) 下观察到神经保护作用,而在低浓度下则观察到神经毒性。它在番木鳖碱-不敏感性甘氨酸位点能够增强激动剂效应。在细胞增殖和分化中发挥作用;抑制神经元一氧化氮合成酶 (nNOS)。

参考文献