Pifithrin-α

• 产品号: P4359
• CAS号: 63208-82-2
• 分子式: C16H19BrN2OS
• 分子量: 367.30386
• 纯 度: ≥95% (HPLC)
• 保 存: protect from light

产品别名

• 标题: Pifithrin-α
• IUPAC标准名: 2-(2-imino-2,3,4,5,6,7-hexahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethan-1-one hydrobromide
• IUPAC传统名: 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone hydrobromide
• 别名: 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide; PFT-α

产品登记号

• CAS号: 63208-82-2
• PubChem SID: 24898529
• MDL号: MFCD00417851

产品性质

• 纯度: ≥95% (HPLC)
• 运输包装: wet ice
• 外观: off-white powder
• 熔点: 192.1-192.5 °C(lit.)
• 溶解度: DMSO: soluble20 mg/mL
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存条件: protect from light
• 保存条件: under inert gas
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Pifithrin-α is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. Pifithrin-α enhances cell survival after genotoxic stress such as UV irradiation and treatment with cytotoxic compounds including doxorubicin, etopoxide, paclitaxel, and cytosine-β-D-arabinofuranoside. Pifithrin-α protects mice from lethal whole body γ-irradiation without an increase in cancer incidence. The protective effect is not seen in p53-null mice or cells expressing a dominant negative mutant of the p53 gene. Protection is conferred by the transient expression of p53 in p53-deficient cell lines.