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Ganciclovir

产品号 G2536 公司名称 Sigma Aldrich
CAS号 82410-32-0 公司网站 http://www.sigmaaldrich.com
分子式 C9H13N5O4 电 话 1-800-521-8956
分子量 255.23062 传 真
纯 度 ≥99% (HPLC) 电子邮件
保 存 Chembase数据库ID: 73249

产品价格信息

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产品别名

标题
Ganciclovir
IUPAC标准名
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-1H-purin-6-one
IUPAC传统名
gancyclovir

产品登记号

PubChem SID 24278453
CAS号 82410-32-0
MDL号 MFCD00870588

产品性质

纯度 ≥99% (HPLC)
产品质量级别 PREMIUM
紫外吸收波长 ε1mM/256 nm 12.0
外观 white powder
溶解度 0.1 M HCl: soluble10 mg/mL
GHS危险品标识 GHS08
GHS警示词 Danger
GHS危险声明 H360
欧盟危险性物质标志 有毒(Toxic) 有毒(Toxic) (T)
个人保护装置 Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS警示性声明 P201-P308 + P313
危险公开号 46-60-61
RTECS编号 MF8407000
安全公开号 53-36/37/39-45
保存温度 2-8°C
德国WGK号 3

产品详细信息

详细说明 (English)
Application
Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required.
Biochem/physiol Actions
Ganciclovir is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research.Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell.1 The cell cycle is irreversibly arrested at the G2-M checkpoint.2 Gap junction involvement in the ganciclovir bystander effect has been studied.3 Ganciclovir has been used to study loss of telomeres4 and to evaluate sensitivity of viruses to antiviral treatments.5

参考文献