Rottlerin

• 产品号: R5648
• CAS号: 82-08-6
• 分子式: C30H28O8
• 分子量: 516.53852
• 纯 度: ≥85%

产品别名

• 标题: Rottlerin
• IUPAC标准名: (2E)-1-{6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl}-3-phenylprop-2-en-1-one
• IUPAC传统名: rottlerin
• 别名: 1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one; Mallotoxin

产品登记号

• CAS号: 82-08-6
• PubChem SID: 24278679
• MDL号: MFCD00017361
• EC号: 201-395-4

产品性质

• 纯度: ≥85%
• 相关基因信息: human ... CDK2(1017)
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS编号: AM6913800
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Recently, Rottlerin (mallotoxin) has been shown to be a potent activator of the large conductance voltage and Ca2 activated K+ channel and to potently leftward shift the conductance-voltage relationship of the channel. Mallatoxin tested on hERG channels increased both step and tail hERG current by leftward shifting the voltage dependence of hERG activation and slowing channel deactivation. These actions distinguish Mallatoxin as a novel naturally occurring hERG channel activator.