(+)-MK-801 hydrogen maleate

• 产品号: M107
• CAS号: 77086-22-7
• 分子式: C20H19NO4
• 分子量: 337.36916

产品别名

• 标题: (+)-MK-801 hydrogen maleate
• IUPAC标准名: (1S,9R)-1-methyl-16-azatetracyclo[7.6.1.0^2,^7.0^1^0,^1^5]hexadeca-2,4,6,10(15),11,13-hexaene; (2Z)-but-2-enedioic acid
• IUPAC传统名: (1S,9R)-1-methyl-16-azatetracyclo[7.6.1.0^2,^7.0^1^0,^1^5]hexadeca-2,4,6,10(15),11,13-hexaene; maleic acid
• 别名: (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate; Dizocilpine hydrogen maleate

产品登记号

• MDL号: MFCD00082465
• EC号: 278-614-5
• PubChem SID: 24277988
• CAS号: 77086-22-7

产品性质

• 相关基因信息: human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907)mouse ... GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168)rat ... GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)
• 外观: white powder
• 比旋光度: [α]25/D +117°, c = 1 in methanol(lit.)
• 溶解度: DMSO: >20 mg/mL
• 溶解度: H2O: soluble6 mg/mL
• 溶解度: 0.1 M HCl: soluble
• 溶解度: ethanol: soluble
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS编号: HP1093575
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Highly potent and selective non-competitive NMDA glutamate receptor antagonist that acts at the NMDA receptor-operated ion channel as an open channel blocker. Inhibits behavioral sensitization to psychostimulants and ethanol.