Polymyxin B nonapeptide hydrochloride

• 产品号: P2076
• 分子式: C43H74N14O11
• 分子量: 963.13486

产品别名

• 标题: Polymyxin B nonapeptide hydrochloride
• IUPAC标准名: 2-amino-N-(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)-3-hydroxybutanamide
• IUPAC传统名: 2-amino-N-(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)-3-hydroxybutanamide
• 别名: PMBN

产品登记号

• MDL号: MFCD00214217
• PubChem SID: 24898270

产品性质

• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Polymyxin B nonapeptide (PMBN), a cationic cyclic peptide derived from the antibacterial peptide polymyxin B, specifically increases the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics.1,2,3 PMBN has been used to evaluate multidrug efflux inhibitors in E. coli.4
Polymyxin B nonapeptide hydrochloride is a derivative of PMB that induces outer membrane permeability in gram-negative bacteria.