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Antipain dihydrochloride from microbial source_分子结构_CAS_37682-72-7)
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Antipain dihydrochloride from microbial source

产品号 A6191 公司名称 Sigma Aldrich
CAS号 37682-72-7 公司网站 http://www.sigmaaldrich.com
分子式 C27H46Cl2N10O6 电 话 1-800-521-8956
分子量 677.62354 传 真
纯 度 电子邮件
保 存 Chembase数据库ID: 133234

产品价格信息

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产品别名

标题
Antipain dihydrochloride from microbial source
IUPAC标准名
2-({[(1S)-4-carbamimidamido-1-{[(1S)-1-[(5-carbamimidamido-1-oxopentan-2-yl)carbamoyl]-2-methylpropyl]carbamoyl}butyl]carbamoyl}amino)-3-phenylpropanoic acid dihydrochloride
IUPAC传统名
2-({[(1S)-4-carbamimidamido-1-{[(1S)-1-[(5-carbamimidamido-1-oxopentan-2-yl)carbamoyl]-2-methylpropyl]carbamoyl}butyl]carbamoyl}amino)-3-phenylpropanoic acid dihydrochloride
别名
N-(Nα-Carbonyl-Arg-Val-Arg-al)-Phe

产品登记号

MDL号 MFCD00135957
CAS号 37682-72-7
PubChem SID 24891067

产品性质

产品质量级别 PREMIUM
溶解度 H2O: soluble50 mg/mL
溶解度 1-butanol: soluble
溶解度 1-propanol: soluble
溶解度 DMSO: soluble
溶解度 ethanol: soluble
溶解度 methanol: soluble
个人保护装置 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS编号 YV9350800
保存温度 -20°C
德国WGK号 3

产品详细信息

详细说明 (English)
Application
Concentrations for 50% inhibition (μg/ml): papain, 0.16trypsin, 0.26cathepsin A, 1.19cathepsin B, 0.59cathepsin D, 125plasmin, >93chymotrypsin and pepsin, >250It also has been reported to inhibit calpain I, (porcine) with Ki = 1.4 μM
Preparation Note
Solubility testing at 50 mg/ml in water yields a clear to slightly hazy yellow solution. It is reportedly soluble in methanol, water, and DMSO; less soluble in ethanol, butanol, and propanol; insoluble in benzene, hexane, and chloroform.8 A stock solution in water or buffer is stable for about a month at -20 °C.Dilute solutions should be stored on ice and kept for only a day because of the terminal aldehyde, which is subject to oxidation and racemization.
Stock solutions in water or buffer stable for 1 week at 4 °C, 1 month at -20 °C.
Biochem/physiol Actions
Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.1

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