Dacarbazine

• 产品号: D2390
• CAS号: 4342-03-4
• 分子式: C6H10N6O
• 分子量: 182.1832

产品别名

• 标题: Dacarbazine
• IUPAC标准名: 5-[(1E)-dimethyltriaz-1-en-1-yl]-1H-imidazole-4-carboxamide
• IUPAC传统名: dacarbazine
• 别名: 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide; DTIC

产品登记号

• CAS号: 4342-03-4
• PubChem SID: 24893683
• EC号: 224-396-1
• MDL号: MFCD00057167

产品性质

• GHS警示词: Danger
• GHS危险声明: H312-H315-H319-H332-H335-H350
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P201-P261-P280-P305 + P351 + P338-P308 + P313
• 危险公开号: 45-46-20/21/22-36/37/38
• RTECS编号: NI3950000
• 安全公开号: 53-36/37/39-45
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents. It is used to induce apoptosis in human cells1. It has been used to induce hepatotoxicity in mice2.
Biochem/physiol Actions
Dacarbazine has significant activity against melanomas. It is a synthetic analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). Dacarbazine appears to exert cytotoxic effects by acting as an alkylating agent, by inhibiting DNA synthesis as a purine analog, and by inducing apoptosis1. Dacarbazine is not cell cycle-phase specific.