Kainic acid monohydrate

• 产品号: K0250
• CAS号: 58002-62-3
• 分子式: C10H17NO5
• 分子量: 231.24568
• 纯 度: ≥99% (TLC)

产品别名

• 标题: Kainic acid monohydrate
• IUPAC标准名: (2S,3S,4S)-3-(carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid hydrate
• IUPAC传统名: kainic acid hydrate
• 别名: 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine

产品登记号

• CAS号: 58002-62-3
• PubChem SID: 24277985
• MDL号: MFCD00150833

产品性质

• 杂质: Glutamate, free
• 纯度: ≥99% (TLC)
• 相关基因信息: human ... GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901), SLC1A1(6505), SLC1A2(6506), SLC1A3(6507)mouse ... Gria1(14799)rat ... Gria1(50592), Grik1(29559), Grik4(24406), Grin2a(24409)
• 溶解度: H2O: soluble
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Kainic acid is used to study mechanisms of excitation-induced apoptosis and epilepsy.
General description
Kainic acid is an agonist for kainate-class ionotropic glutamate receptors. Kainate receptors directly gate ion channels and are generally excitatory. Excess stimulation by Kainic acid induces neurocytosis (apoptosis) and epileptic seizures.
Preparation Note
Dissolve in 1-2 drops of 1N NaOH then bring to volume with water or aqueous buffer. Can be stored 1-2 days refrigerated.
Biochem/physiol Actions
Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.