Trifluorothymidine

• 产品号: T2255
• CAS号: 70-00-8
• 分子式: C10H11F3N2O5
• 分子量: 296.1999496
• 纯 度: ≥99% (HPLC)

产品别名

• 标题: Trifluorothymidine
• IUPAC标准名: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
• IUPAC传统名: trifluridine
• 别名: 2′-Deoxy-5-trifluoromethyluridine; Trifluridine; α,α,α-Trifluorothymidine; Trifluorothymine deoxyriboside

产品登记号

• EC号: 200-722-8
• MDL号: MFCD00006534
• PubChem SID: 24900027
• CAS号: 70-00-8

产品性质

• 纯度: ≥99% (HPLC)
• 熔点: 190-193 °C(lit.)
• GHS警示词: Warning
• GHS危险声明: H302-H312-H332-H351
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P280
• 危险公开号: 20/21/22-40
• RTECS编号: XP2087500
• 安全公开号: 22-36
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Trifluorothymidine (Trifluridine, TFT) is a substrate used to study the specificity and kinetics of thymidine kinase(s). TFT after phosphorylation may be incorporated into DNA where is induces DNA-damage, consequently TFT is useful for studies of DNA repair mechanisms. TFT may also be used to study mechanisms of inhibition of thymidylate synthase(s).