磷霉素 二钠盐

• 产品号: P5396
• CAS号: 26016-99-9
• 分子式: C3H5Na2O4P
• 分子量: 182.022701

产品别名

• 标题: Phosphomycin disodium salt
• IUPAC标准名: disodium [(2R,3S)-3-methyloxiran-2-yl]phosphonate
• IUPAC传统名: disodium fosfomycin(2-)
• 别名: Phosphonomycin; (-)-(1R,2S)-(1,2-环氧丙基)膦酸; Fosfomycin

产品登记号

• PubChem SID: 24278640
• CAS号: 26016-99-9
• Beilstein号: 4604425
• EC号: 247-409-2

产品性质

• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS编号: SZ7902000
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Application
Phosphomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections and to reduce nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. It is used for susceptibility studies of Klebsiella pneumoniae1 and to study in vitro susceptibility testing procedures for fosfomycin tromethamine2.
Biochem/physiol Actions
Fosfomycin is a phosphoenolpyruvate analog. It irreversibly inhibits enolpyruvate transferase (MurA). Therefore, the producion of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall is inhibited.
聚集在肾脏和膀胱中的抗生素；降低含铂抗肿瘤制剂的肾毒性和耳毒性。磷霉素可以抑制 UDP-GlcNAc 烯醇式丙酮酸转移酶 (MurA)（细菌细胞壁生物合成中的酶）。