Ouabain octahydrate

• 产品号: O3125
• CAS号: 11018-89-6
• 分子式: C29H60O20
• 分子量: 728.7747
• 纯 度: ≥95% (HPLC)

产品别名

• 标题: Ouabain octahydrate
• IUPAC标准名: 4-[(1S,2R,3R,5S,7S,10R,11S,14R,15R,17R)-3,7,11,17-tetrahydroxy-2-(hydroxymethyl)-15-methyl-5-{[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecan-14-yl]-2,5-dihydrofuran-2-one octahydrate
• IUPAC传统名: ouabain octahydrate
• 别名: 1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside); G-Strophanthin; Acocantherine

产品登记号

• EC号: 211-139-3
• PubChem SID: 24278610
• MDL号: MFCD00149240
• CAS号: 11018-89-6
• Beilstein号: 101712

产品性质

• 杂质: ~8 mol/mol water
• 纯度: ≥95% (HPLC)
• 相关基因信息: human ... ATIC(471)rat ... Atp1b1(25650)
• 紫外吸收波长: ε1mM/220 nm, H2O 15.5
• 外观: white powder
• 比旋光度: [α]25/D -31 to -32.5° in H2O(lit.)
• 溶解度: H2O: soluble10 mg/mL (cold)
• 溶解度: ethanol: soluble10 mg/mL
• 溶解度: H2O: soluble50 mg/mL (hot)
• GHS警示词: Danger
• GHS危险声明: H301 + H331-H373
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• GHS警示性声明: P261-P301 + P310-P311
• RID/ADR: UN 1544 6.1/PG 1
• 危险公开号: 23/25-33
• 安全公开号: 45
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 1544
• 联合国危险货物包装类别(PG): 1
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Caution
Aqueous solutions can be autoclaved.
Biochem/physiol Actions
Cardiac glycoside, inhibits Na(+)/K(+) ATPase, regulates transcription of MDR (increase, Pgp) and MRP (increase MRP1 and decrease CFTR, cyctic fibrosis transport receptor or cAMP-activated Cl- channel) genes, also alters localization of MRP1. Ouabain resistance is associated with appearance of Na(+)/K(+) ATPase isoforms with low binding affinity.