Streptonigrin from Streptomyces flocculus

• 产品号: S1014
• CAS号: 3930-19-6
• 分子式: C25H22N4O8
• 分子量: 506.46418
• 纯 度: ≥98%

产品别名

• 标题: Streptonigrin from Streptomyces flocculus
• IUPAC标准名: 5-amino-6-(7-amino-6-methoxy-5,8-dioxo-5,8-dihydroquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpyridine-2-carboxylic acid
• IUPAC传统名: nigrin
• 别名: Bruneomycin; Nigrin

产品登记号

• CAS号: 3930-19-6
• PubChem SID: 24899458
• MDL号: MFCD00063401
• Beilstein号: 599390
• EC号: 223-501-8

产品性质

• 纯度: ≥98%
• GHS警示词: Danger
• GHS危险声明: H300
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• 个人保护装置: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P264-P301 + P310
• RID/ADR: UN 3462 6.1/PG 1
• 危险公开号: 28
• RTECS编号: TJ7350000
• 安全公开号: 53-28-36/37/39-45
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 3462
• 联合国危险货物包装类别(PG): 1
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Streptonigrin (SN) is an aminoquinone antitumour antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by SN are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated.