D-青霉胺

• 产品号: P4875
• CAS号: 52-67-5
• 分子式: C5H11NO2S
• 分子量: 149.21134
• 纯 度: 98-101%

产品别名

• 标题: D-Penicillamine
• IUPAC标准名: (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid
• IUPAC传统名: depen
• 别名: 3,3-二甲基-D-半胱氨酸; D-(-)-2-氨基-3-巯基-3-甲基丁酸; 3-巯基-D-缬氨酸

产品登记号

• MDL号: MFCD00064302
• EC号: 200-148-8
• CAS号: 52-67-5
• PubChem SID: 24898564
• Beilstein号: 1722375

产品性质

• 纯度: 98-101%
• 相关基因信息: mouse ... Oprk1(18387)
• 熔点: 210 °C (dec.)(lit.)
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• RTECS编号: YV9425000
• 安全公开号: 26-36
• 保存温度: 2-8°C
• 德国WGK号: 2

产品详细信息

详细说明 (简体中文)

包装
5, 25 g in poly bottle
Application
It is used as an antirheumatic and as a chelating agent in Wilson′s disease. It is used as a copper chelator to form mixed disulfides with cysteine or other sulfide media components. It is used to inactivate protein-1 DNA binding1 and to inhibit the growth of asynchronous cultures of rabbit articular chondrocytes2.
Biochem/physiol Actions
Penicillamine is a haracteristic degradation product of penicillin type antibiotics. One atom of copper combines with two molecules of penicillamine. Penicillamine reduces excess cystine excretion in cystinuria. This is by disulfide interchange between penicillamine and cystine, which results in formation of a readily excreted penicillamine-cysteine disulfide. Penicillamine interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed. Penicillamine lowers IgM rheumatoid factor and depresses T-cell activity.