Etoposide

• 产品号: E1383
• CAS号: 33419-42-0
• 分子式: C29H32O13
• 分子量: 588.55658
• 纯 度: ≥98%

产品别名

• 标题: Etoposide
• IUPAC标准名: (10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^3,^7.0^1^1,^1^5]hexadeca-1,3(7),8-trien-12-one
• IUPAC传统名: etoposide
• 别名: VP-16-213; 4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside)

产品登记号

• MDL号: MFCD00869325
• EC号: 251-509-1
• PubChem SID: 24278178
• CAS号: 33419-42-0

产品性质

• 生物来源: synthetic
• 纯度: ≥98%
• 相关基因信息: human ... ABCB1(5243), CYP3A4(1576), TOP2A(7153)mouse ... Abcb1a(18671), Abcb1b(18669)rat ... Top2a(360243)
• pKa: 9.8
• 外观: white powder
• 熔点: 236-251 °C(lit.)
• 溶解度: DMSO: soluble30 mg/mL
• GHS警示词: Danger
• GHS危险声明: H302-H350
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P201-P308 + P313
• 危险公开号: 45-22
• RTECS编号: KC0190000
• 安全公开号: 53-45
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Etoposide is an antitumor agent that complexes with topoisomerase II and DNA to enhance double-strand and single-strand cleavage of DNA and reversibly inhibit religation. Blocks the cell cycle in in S-phase and G2-phase of the cell cycle; induces apoptosis in normal and tumor cell lines; inhibits synthesis of the oncoprotein Mdm2 and induces apoptosis in tumor lines that overexpress Mdm2.