Sulindac sulfide

• 产品号: S3131
• CAS号: 32004-67-4
• 分子式: C20H17FO2S
• 分子量: 340.4111832
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Sulindac sulfide
• IUPAC标准名: 2-[(1Z)-5-fluoro-2-methyl-1-{[4-(methylsulfanyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid
• IUPAC传统名: [(3Z)-6-fluoro-2-methyl-3-{[4-(methylsulfanyl)phenyl]methylidene}inden-1-yl]acetic acid
• 别名: (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid

产品登记号

• MDL号: MFCD00869764
• CAS号: 32004-67-4
• EC号: 250-892-2
• PubChem SID: 24899543

产品性质

• 纯度: ≥98% (HPLC)
• 外观: yellow solid
• 溶解度: DMSO: ≥22 mg/mL
• GHS警示词: Danger
• GHS危险声明: H302-H317-H334-H361
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P261-P280-P342 + P311
• 危险公开号: 63-22-42/43
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Sulindac sulfide is a non-steroidal anti-inflammatory compound with a preference for COX-1; it is an inhibitor of Ras activation of Raf-1. It impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP. It is an active metabolite of sulindac. It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism.