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Rapamycin from Streptomyces hygroscopicus_分子结构_CAS_53123-88-9)
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Rapamycin from Streptomyces hygroscopicus

产品号 R0395 公司名称 Sigma Aldrich
CAS号 53123-88-9 公司网站 http://www.sigmaaldrich.com
分子式 C51H79NO13 电 话 1-800-521-8956
分子量 914.17186 传 真
纯 度 ≥95% (HPLC) 电子邮件
保 存 Chembase数据库ID: 132924

产品价格信息

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产品别名

标题
Rapamycin from Streptomyces hygroscopicus
IUPAC标准名
(1R,9S,12S,15R,16Z,18R,19R,21R,23S,24Z,26Z,28Z,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
IUPAC传统名
(1R,9S,12S,15R,16Z,18R,19R,21R,23S,24Z,26Z,28Z,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
别名
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine
Sirolimus
AY 22989

产品登记号

PubChem SID 24899339
MDL号 MFCD00867594
CAS号 53123-88-9

产品性质

溶解度 ethanol: soluble2 mM
溶解度 DMSO: soluble
外观 off-white powder
个人保护装置 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS编号 VE6250000
保存温度 -20°C
德国WGK号 2
纯度 ≥95% (HPLC)
产品质量级别 PREMIUM
相关基因信息 human ... FKBP1A(2280)

产品详细信息

详细说明 (English)
Frequently Asked Questions
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Biochem/physiol Actions
A macrocyclic triene antibiotic that binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

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