Trichostatin A

• 产品号: T8552
• CAS号: 58880-19-6
• 分子式: C17H22N2O3
• 分子量: 302.36818
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Trichostatin A
• IUPAC标准名: (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
• IUPAC传统名: trichostatin a
• 别名: TSA; [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

产品登记号

• CAS号: 58880-19-6
• MDL号: MFCD03848392
• PubChem SID: 24900542

产品性质

• 相关基因信息: human ... HDAC1(3065), HDAC4(9759), HDAC6(10013), HDAC8(55869)mouse ... ENSMUSG00000061062(15181)rat ... Hdac7a(84582)
• 溶解度: ethanol: soluble2 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302-H312-H315-H317-H319-H332-H335
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P261-P280-P305 + P351 + P338
• 危险公开号: 20/21/22-36/37/38-43
• RTECS编号: MI5215000
• 安全公开号: 26-36
• 保存温度: -20°C
• 德国WGK号: 3
• 生物来源: from Streptomyces sp.
• 纯度: ≥98% (HPLC)
• 产品质量级别: PREMIUM

产品详细信息

详细说明 (English)

Frequently Asked Questions
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Biochem/physiol Actions
Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA.