Leptomycin B solution from Streptomyces sp.

• 产品号: L2913
• CAS号: 87081-35-4
• 分子式: C33H48O6
• 分子量: 540.73062
• 纯 度: ≥95% (HPLC)

产品别名

• 标题: Leptomycin B solution from Streptomyces sp.
• IUPAC标准名: (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid
• IUPAC传统名: leptomycin B

产品登记号

• CAS号: 87081-35-4
• PubChem SID: 24896330
• MDL号: MFCD06795848

产品性质

• 纯度: ≥95% (HPLC)
• 产品质量级别: PREMIUM
• 运输包装: dry ice
• 闪点: 18 °C
• 闪点: 64.4 °F
• GHS警示词: Danger
• GHS危险声明: H225-H301-H311-H331-H370
• 欧盟危险性物质标志: 易燃性(Flammable) (F)
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• GHS警示性声明: P210-P260-P280-P301 + P310-P311
• RID/ADR: UN 1230 3/PG 2
• 危险公开号: 11-23/24/25-39/23/24/25
• 安全公开号: 16-36/37-45
• 保存温度: -20°C
• 联合国危险货物等级: 3
• 联合国危险货物编号: 1230
• 联合国危险货物包装类别(PG): 2
• 德国WGK号: 1

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Leptomycin B is an unsaturated, branched-chain fatty acid, and is an important tool in the study of nuclear export. It is a specific inhibitor of proteins containing nuclear export signal. It inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA. The addition of very small amounts to fibroblasts causes accumulation of MEK in the nucleus. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, IκB, MPF, and PKA. The suggested inhibition mechanism involves the direct binding of leptomycin B to CRM1, which blocks the binding of CRM1 to proteins containing the nuclear export signal, via the interaction with cysteine residue in CRM1 control conserved region.
General description
Leptomycin B is an anti-fungal antibiotic, anti-tumor cytotoxin that inhibits CRM1-dependent, NES-dependent nucleo-cytoplasmic translocation (nuclear export inhibitor). NES containing proteins include HIV-1 REV; actin, c-Abl, cyclin B1, MDM2/p53, I?B, MPF, PKA and MEK.