壮观霉素 二盐酸盐 五水合物

• 产品号: S9007
• CAS号: 22189-32-8
• 分子式: C14H36Cl2N2O12
• 分子量: 495.34784

产品别名

• 标题: Spectinomycin dihydrochloride pentahydrate
• IUPAC标准名: (1R,3S,5R,8R,10R,11S,12S,13R,14S)-8,12,14-trihydroxy-5-methyl-11,13-bis(methylamino)-2,4,9-trioxatricyclo[8.4.0.0^3,^8]tetradecan-7-one pentahydrate dihydrochloride
• IUPAC传统名: prospec pentahydrate dihydrochloride

产品登记号

• MDL号: MFCD00150886
• PubChem SID: 24899822
• CAS号: 22189-32-8
• EC号: 244-554-3

产品性质

• 药效: ≥603 μg per mg
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C
• 德国WGK号: 2

产品详细信息

详细说明 (简体中文)

Application
Used as a selection agent for transformed plant cells that contain the selectable marker gene Spcr and to inhibit bacterial protein synthesis at the level of peptidy tRNA translocation.
Biochem/physiol Actions
作用方式：通过干扰肽基 tRNA 的转位抑制蛋白质合成（延伸）。 抗菌谱：革兰氏阴性和革兰氏阳性菌（仅包括淋球菌）。 抗性机理：rpsE（核糖体蛋白 S5 的基因）的突变可阻止壮观霉素的结合。
Spectinomycin is a broad spectrum antibiotic that inhibits protein synthesis (elongation) by binding to the bacterial 30S ribosomal subunit and interfering with peptidyl tRNA translocation. Resistance to spectinomycin is conferred by aminoglycoside-3′-adenyltransferase gene (aadA). It is effective against Gram-negative and Gram-positive bacteria. Mutation in rpsE (the gene for ribosomal protein S5) prevents binding of spectinomycin.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information