L-Mimosine from Koa hoale seeds

• 产品号: M0253
• CAS号: 500-44-7
• 分子式: C8H10N2O4
• 分子量: 198.176
• 纯 度: ≥98%

产品别名

• 标题: L-Mimosine from Koa hoale seeds
• IUPAC标准名: (2S)-2-amino-3-(3-hydroxy-4-oxo-1,4-dihydropyridin-1-yl)propanoic acid
• IUPAC传统名: mimosine
• 别名: Leucenol; (S)-α-Amino-β-[1-(3-hydroxy-4-oxopyridine)]propionic acid

产品登记号

• MDL号: MFCD00075909
• CAS号: 500-44-7
• EC号: 207-905-1
• PubChem SID: 24896541

产品性质

• 纯度: ≥98%
• GHS警示词: Warning
• GHS危险声明: H302-H312-H332
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P280
• 危险公开号: 20/21/22
• 安全公开号: 22-36
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
L-Mimosine is a plant amino acid and potential inhibitor of the cell cycle giving rise to growth arrest in G1-phase. An iron chelator that inhibits DNA replication in mammalian cells. Has been shown to have apoptotic activity in xenotransplanted human pancreatic cancer. L-Mimosine is also used as a hypoxia-mimetic agent to stabilize Hypoxia Inducible Factor 1 (HIF-1). L-Mimosine stabilizes HIF-1 through the inhibition of Prolyl Hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity.