(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate

• 产品号: T200
• CAS号: 182485-36-5(anhydrous)
• 分子式: C6H14NO3P
• 分子量: 179.154021
• 纯 度: ≥97% (NMR)

产品别名

• 标题: (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate
• IUPAC标准名: P-methyl-1,2,3,6-tetrahydropyridin-1-ium-4-phosphinate hydrate
• IUPAC传统名: P-methyl-1,2,3,6-tetrahydropyridin-1-ium-4-phosphinate hydrate
• 别名: TPMPA hydrate

产品登记号

• PubChem SID: 24278172
• CAS号: 182485-36-5(anhydrous)

产品性质

• 纯度: ≥97% (NMR)
• 外观: white to off-white solid
• 溶解度: H2O: soluble16 mg/mL
• 溶解度: DMSO: insoluble
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Legal Information
Sold in the USA under exclusive license from the University of California.
Biochem/physiol Actions
TPMPA is a hybrid of isoguvacine and 3-APMPA designed to retain affinity for GABAC receptors but not to interact with GABAA or GABAB receptors. Electrical assays show that TPMPA is a competitive antagonist of cloned human mu 1 GABAC receptors expressed in Xenopus laevis oocytes (Kb approx. 2 μM). TPMPA is >100-fold weaker as an inhibitor of rat brain GABAA receptors expressed in oocytes (Kb approx. 320 μM) and has only weak agonist activity on GABAB receptors assayed in rat hippocampal slices (EC50 approx. 500 μM). TPMPA may be used to investigate GABAC receptor function in the outer retina and in any other areas of the nervous system in which these types of receptor are present.