Ribavirin

• 产品号: R9644
• CAS号: 36791-04-5
• 分子式: C8H12N4O5
• 分子量: 244.20468

产品别名

• 标题: Ribavirin
• IUPAC标准名: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
• IUPAC传统名: ribavirin
• 别名: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

产品登记号

• MDL号: MFCD00058564
• PubChem SID: 24278685
• CAS号: 36791-04-5

产品性质

• 相关基因信息: human ... IMPDH1(3614), IMPDH2(3615)
• GHS警示词: Danger
• GHS危险声明: H360
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P201-P308 + P313
• 危险公开号: 61
• RTECS编号: XZ4250000
• 安全公开号: 53-22-45
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Antiviral agent. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase. Used to inhibit purine (GTP pools) biosynthesis at the level of inosine monophosphate (IMP) dehydrogenase and as a precursor to the di- and tri-phosphates which inhibit viral RNA-dependent RNA polymerases.
Antiviral agent used against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase, but many other mechanisms of action are also supported with experimental evidence.1
General description
Analog of the imidazole nucleotide intermediates in purine nucleotide biosynthesis.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. R9644.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.