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Cinoxacin

产品号 C8645 公司名称 Sigma Aldrich
CAS号 28657-80-9 公司网站 http://www.sigmaaldrich.com
分子式 C12H10N2O5 电 话 1-800-521-8956
分子量 262.2182 传 真
纯 度 电子邮件
保 存 Chembase数据库ID: 706

产品价格信息

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产品别名

标题
Cinoxacin
IUPAC标准名
1-ethyl-4-oxo-1H,4H,7H-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid
IUPAC传统名
cinoxacin

产品登记号

MDL号 MFCD00056776
PubChem SID 24278343
CAS号 28657-80-9
EC号 249-133-8

产品性质

个人保护装置 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS编号 JI4640000
德国WGK号 2

产品详细信息

详细说明 (English)
Application
Cinoxacin is a synthetic antimicrobial commonly used in urinary tract infections that are caused by Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella species, and Enterobacter species.. It is a quinolone gyrase inhibitor. It is used to study the rat renal organic anion transporter 1 (OAT1)1. It is used to study fluoroquinolone-resistant Streptococcus pyogenes2.
Biochem/physiol Actions
Cinoxacin interferes with DNA replication by inhibiting DNA gyrase and topoisomerase IV (topo IV) through tight DNA binding. Cinoxacin allows for proper replicated DNA separation. Therefore, the inhibition of Cinoxacin inhibits DNA replication and cell division.
Cinoxacin interferes with DNA replication by inhibiting DNA gyrase and topoisomerase IV (topo IV) through tight DNA binding.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C8645.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

参考文献