Cloxacillin sodium salt monohydrate

• 产品号: C9393
• CAS号: 7081-44-9
• 分子式: C19H20ClN3NaO6S
• 分子量: 476.88637

产品别名

• 标题: Cloxacillin sodium salt monohydrate
• IUPAC标准名: (2S,5R,6R)-6-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid hydrate sodium
• IUPAC传统名: cloxacillin hydrate sodium

产品登记号

• PubChem SID: 24893156
• MDL号: MFCD00150735
• CAS号: 7081-44-9
• EC号: 211-390-9

产品性质

• 适用性: suitable for 1694 per US EPA
• GHS警示词: Danger
• GHS危险声明: H315-H317-H319-H334-H335
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P261-P280-P305 + P351 + P338-P342 + P311
• 危险公开号: 36/37/38-42/43
• RTECS编号: XH8920000
• 安全公开号: 26-36
• 保存温度: 2-8°C
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Application
Cloxacillin is a semi-synthetic antibiotic that is a chlorinated derivative of oxacillin. It is also known as cloxacillin sodium. It is used to treat infections caused by penicillin G-resistant staphylococci1. It has been used in studies of topical antibacterial agent for burn and crush wounds2.
Biochem/physiol Actions
Cloxacillin inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins (PBPs), which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Cloxacillin may interfere with autolysin inhibitors. Cloxacillin is used as an AmpC β-lactamase inhibitor in combination with β-lactam antibiotics.
Cloxacillin is used as an AmpC β-lactamase inhibitor in combination with β-lactam antibiotics.