Suramin sodium salt

• 产品号: S2671
• CAS号: 129-46-4
• 分子式: C51H34N6Na6O23S6
• 分子量: 1429.17068
• 纯 度: ≥95%

产品别名

• 标题: Suramin sodium salt
• IUPAC标准名: hexasodium 8-{4-methyl-3-[3-({[3-({2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzamido]benzamido}naphthalene-1,3,5-trisulfonate
• IUPAC传统名: hexasodium 8-{4-methyl-3-[3-({[3-({2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzamido]benzamido}naphthalene-1,3,5-trisulfonate
• 别名: Suramine sodium salt

产品登记号

• PubChem SID: 24277738
• CAS号: 129-46-4
• EC号: 204-949-3
• MDL号: MFCD00210217
• Beilstein号: 3694087

产品性质

• 纯度: ≥95%
• 相关基因信息: human ... EGF(1950), P2RX1(5023), P2RY1(5028), PDGFA(5154), PLD1(5337)
• 溶解度: H2O: >10 mg/mL
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS编号: QM7000000
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity.