R(+)-Methanandamide

• 产品号: M186
• CAS号: 157182-49-5
• 分子式: C23H39NO2
• 分子量: 361.56126
• 纯 度: ≥96% (HPLC)
• 保 存: desiccated

产品别名

• 标题: R(+)-Methanandamide
• IUPAC标准名: (5Z,8Z,11Z,14Z)-N-[(2R)-1-hydroxypropan-2-yl]icosa-5,8,11,14-tetraenamide
• IUPAC传统名: methanandamide
• 别名: R(+)-Arachidonyl-1′-hydroxy-2′-propylamide; AM-356

产品登记号

• MDL号: MFCD00467914
• PubChem SID: 24896698
• EC号: 200-578-6
• CAS号: 157182-49-5

产品性质

• 闪点: 57.2 °F
• 比旋光度: [α]/D +8.7°, c = 4 in chloroform(lit.)
• 闪点: 14 °C
• 毒品管制信息: regulated under CDSA - not available from Sigma-Aldrich Canada
• GHS警示词: Danger
• GHS危险声明: H225
• 欧盟危险性物质标志: 易燃性(Flammable) (F)
• 个人保护装置: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS警示性声明: P210
• RID/ADR: UN 1170 3/PG 2
• 危险公开号: 11
• 安全公开号: 7-16
• 保存条件: desiccated
• 保存条件: protect from light
• 保存条件: under inert gas
• 保存温度: -20°C
• 联合国危险货物等级: 3
• 联合国危险货物编号: 1170
• 联合国危险货物包装类别(PG): 2
• 德国WGK号: 2
• 浓度: 5 mg/mL in absolute ethanol
• 纯度: ≥96% (HPLC)
• 相关基因信息: mouse ... Cnr1(12801), Cnr2(12802)rat ... Cnr1(25248)

产品详细信息

详细说明 (English)

Biochem/physiol Actions
R(+)-Methanandamide is metabolically stable congener of anandamide that has higher affinity for the cannabinoid receptor. Of the analogs tested, (R)-methanandamide exhibited the highest affinity for the cannabinoid receptor with a Ki of 20 +/- 1.6 nM, 4-fold lower than that of anandamide (Ki = 78 +/- 2 nM). (R)-methanandamide exhibits high stability to aminopeptidase hydrolysis. Experiments with mice have demonstrated that (R)-methanandamide also posseses cannabimimetric properties in vivo, as established by the four tests of hypothermia, hypokinesia, ring immobility, and antinociception.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. M186.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.