Netropsin dihydrochloride

• 产品号: N9653
• CAS号: 1438-30-8
• 分子式: C18H28Cl2N10O3
• 分子量: 503.38612
• 纯 度: ≥98% (HPLC and TLC)

产品别名

• 标题: Netropsin dihydrochloride
• IUPAC标准名: 4-[4-(2-carbamimidamidoacetamido)-1-methyl-1H-pyrrole-2-amido]-N-(2-carbamimidoylethyl)-1-methyl-1H-pyrrole-3-carboxamide dihydrochloride
• IUPAC传统名: 4-[4-(2-carbamimidamidoacetamido)-1-methylpyrrole-2-amido]-N-(2-carbamimidoylethyl)-1-methylpyrrole-3-carboxamide dihydrochloride
• 别名: Sinanomycin; Congocidin

产品登记号

• CAS号: 1438-30-8
• PubChem SID: 24897909
• MDL号: MFCD00144883

产品性质

• 生物来源: from Streptomyces netropsis
• 纯度: ≥98% (HPLC and TLC)
• 外观: faint yellow powder
• 溶解度: H2O: soluble1 mg/mL
• GHS警示词: Danger
• GHS危险声明: H301
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 22
• RTECS编号: DW2973000
• 安全公开号: 36
• 保存温度: -20°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Caution
Protect from light.
Biochem/physiol Actions
Netropsin is an unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G.