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Radicicol from Diheterospora chlamydosporia_分子结构_CAS_12772-57-5)
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Radicicol from Diheterospora chlamydosporia

产品号 R2146 公司名称 Sigma Aldrich
CAS号 12772-57-5 公司网站 http://www.sigmaaldrich.com
分子式 C18H17ClO6 电 话 1-800-521-8956
分子量 364.77698 传 真
纯 度 电子邮件
保 存 Chembase数据库ID: 132458

产品价格信息

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产品别名

标题
Radicicol from Diheterospora chlamydosporia
IUPAC标准名
(4R,6R,8R,9Z,11Z)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.06,8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione
IUPAC传统名
(4R,6R,8R,9Z,11Z)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.06,8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione
别名
Monorden
[1aS-(1aR*,2Z,4E,14*,15aR*)]-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione

产品登记号

PubChem SID 24899351
CAS号 12772-57-5
MDL号 MFCD06795865

产品性质

相关基因信息 human ... HSP90AA1(3320), SRC(6714)rat ... Src(83805)
外观 yellow solid
溶解度 ethanol: soluble10 mg/mL
GHS危险品标识 GHS06
GHS危险品标识 GHS08
GHS警示词 Danger
GHS危险声明 H301-H315-H319-H335-H340-H350
欧盟危险性物质标志 有毒(Toxic) 有毒(Toxic) (T)
GHS警示性声明 P201-P261-P301 + P310-P305 + P351 + P338-P308 + P313
RID/ADR UN 2811 6.1/PG 3
危险公开号 45-46-22-36/37/38
安全公开号 53-26-45
保存温度 -20°C
联合国危险货物等级 6.1
联合国危险货物编号 2811
联合国危险货物包装类别(PG) 3
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Antifungal macrolactone antibiotic that inhibits protein tyrosine kinase. Radicicol induces the differentiation of HL-60 cells into macrophages, blocking cell cycle at G1 and G2. It suppresses NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos and also suppresses the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of and plasminogen activator production by vascular endothelial cells.
Caution
Photosensitive

参考文献