DL-Aminoglutethimide

• 产品号: A9657
• CAS号: 125-84-8
• 分子式: C13H16N2O2
• 分子量: 232.27834

产品别名

• 标题: DL-Aminoglutethimide
• IUPAC标准名: 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
• IUPAC传统名: aminoglutethimide
• 别名: 3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione; 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione

产品登记号

• PubChem SID: 24278142
• CAS号: 125-84-8
• MDL号: MFCD00010122
• EC号: 204-756-4

产品性质

• 相关基因信息: human ... CYP17A1(1586), CYP19A1(1588)rat ... Cyp19a1(25147)
• 外观: white
• 熔点: 152-154 °C(lit.)
• 溶解度: H2O: slightly soluble0.2 mg/mL
• 溶解度: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble1.2 mg/mL
• 溶解度: 0.1 M HCl: soluble
• 溶解度: acetonitrile: soluble
• 溶解度: methanol: soluble
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• RTECS编号: MA4026950
• 安全公开号: 26-36
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
DL-Aminoglutethimide is a derivative of the sedative glutethimide. Originally introduced as an anticonvulsant, it was found to cause adrenal insufficiency. Blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone. It also blocks the peripheral conversion (aromatization) of androgenic precursors to estrogens. The D-isomer is 30 times more potent at inhibiting aromatase activity, whereas the L-isomer is more potent at inhibiting cholesterol side-chain cleavage (steroidogenesis).
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A9657.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.