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甲氧苄啶

产品号 T7883 公司名称 Sigma Aldrich
CAS号 738-70-5 公司网站 http://www.sigmaaldrich.com
分子式 C14H18N4O3 电 话 1-800-521-8956
分子量 290.31772 传 真
纯 度 ≥98% (TLC) 电子邮件
保 存 Chembase数据库ID: 323

产品价格信息

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产品别名

标题
Trimethoprim
IUPAC标准名
5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
IUPAC传统名
trimethoprim
别名
2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶

产品登记号

MDL号 MFCD00036761
Beilstein号 625127
PubChem SID 24278201
EC号 212-006-2
CAS号 738-70-5

产品性质

纯度 ≥98% (TLC)
相关基因信息 human ... DHFRP1(573971), KCNH1(3756)rat ... Dhfr(24312)
外观 white powder
溶解度 DMSO: soluble
个人保护装置 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS编号 UV8225000
保存温度 2-8°C
德国WGK号 3

产品详细信息

详细说明 (English)
Application
Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections1.
Other Notes
Specific inhibitor of formulation. Widely used in studies on dihydrofolate reductase2,3.
Biochem/physiol Actions
The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis1.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

参考文献