(±)-Verapamil hydrochloride

• 产品号: V4629
• CAS号: 152-11-4
• 分子式: C27H39ClN2O4
• 分子量: 491.06256
• 纯 度: ≥99.0% (titration)

产品别名

• 标题: (±)-Verapamil hydrochloride
• IUPAC标准名: 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile hydrochloride
• IUPAC传统名: veraβ hydrochloride
• 别名: 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride

产品登记号

• EC号: 205-800-5
• PubChem SID: 24277881
• CAS号: 152-11-4
• Beilstein号: 3647093
• MDL号: MFCD00055208

产品性质

• 纯度: ≥99.0% (titration)
• 相关基因信息: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
• 外观: white powder
• 熔点: 142 °C (dec.)(lit.)
• 溶解度: H2O: soluble50 mg/mL
• 溶解度: ethanol: soluble
• GHS警示词: Danger
• GHS危险声明: H301-H311-H331
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS警示性声明: P261-P280-P301 + P310-P311
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 23/24/25
• RTECS编号: YV8320000
• 安全公开号: 36/37-45
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

包装
1, 5, 10 g in glass bottle
Biochem/physiol Actions
α1-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.