长春新碱 硫酸盐

• 产品号: V8879
• CAS号: 2068-78-2
• 分子式: C46H58N4O14S
• 分子量: 923.03612
• 纯 度: 95.0-105.0% (HPLC)

产品别名

• 标题: Vincristine sulfate salt
• IUPAC标准名: sulfuric acid methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^4,^1^2.0^5,^1^0]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2(7),3,5,13-tetraene-10-carboxylate
• IUPAC传统名: sulfuric acid methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^4,^1^2.0^5,^1^0]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2(7),3,5,13-tetraene-10-carboxylate
• 别名: 醛基长春碱 硫酸盐; 长春醛碱 硫酸盐; VCR

产品登记号

• Beilstein号: 3924631
• PubChem SID: 24278774
• CAS号: 2068-78-2
• EC号: 218-190-0
• MDL号: MFCD00084729

产品性质

• 杂质: ≤12% ethanol(actual content given on label)
• 纯度: 95.0-105.0% (HPLC)
• 外观: white to off-white powder
• 溶解度: methanol: soluble20 mg/mL
• GHS警示词: Danger
• GHS危险声明: H300-H341-H361fd
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• GHS警示性声明: P264-P281-P301 + P310
• RID/ADR: UN 2811 6.1/PG 2
• 危险公开号: 63-25-62-68
• 安全公开号: 36/37-45
• 保存温度: -20°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 2
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Vincristine is an antitumor alkaloid isolated from Vinca Rosea. It is used to treat acute leukaemia, malignant lymphoma, Hodgkin′s disease, acute erythraemia, acute panmyelosis, breast cancer, Kaposi’s sarcoma and testicular cancer. Vincristine is widely used in cancer research. It is used to study multi-drug resistance. It is used to inhibit cell cycle progression at M-phase and to inhibit monoamine oxidase (MAO) 1.
Biochem/physiol Actions
Vincristine is a plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing coiled spiral aggregate formation. It arrests cell cycle in G2/M-phase by blocking mitotic spindle formation2. Vincristine triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. It inhibits VEGF production in leukemia cell lines. It is a substrate for Pgp and CYP3A4. MRP1 transports vincristine in an ATP- and GSH-dependent manner. Vincristine has some immunosuppressant effect. Vincristine may also interfere with amino acid, cyclic AMP, and glutathione metabolism, calmodulin-dependent Ca2+-transport, cellular respiration, and nucleic acid and lipid biosynthesis1.