四环素

• 产品号: T3258
• CAS号: 60-54-8
• 分子式: C22H24N2O8
• 分子量: 444.43456
• 纯 度: ≥88.0% (HPLC)

产品别名

• 标题: Tetracycline
• IUPAC标准名: (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
• IUPAC传统名: tetracycline

产品登记号

• MDL号: MFCD00151232
• EC号: 200-481-9
• PubChem SID: 24900120
• CAS号: 60-54-8
• Beilstein号: 2230417

产品性质

• 纯度: ≥88.0% (HPLC)
• 相关基因信息: human ... CYP1A2(1544), TERT(7015)
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• 危险公开号: 22
• RTECS编号: QI8750000
• 安全公开号: 22-36
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Tetracycline is a broad spectrum polyketide antibiotic. It is used clinically to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, and Brill-Zinsser disease. It is used to treat upper respiratory infections and acne1. It is used to study multidrug resistance2 as well as potential side effects such as acute pancreatitis3.
Biochem/physiol Actions
Tetracycline inhibits bacterial protein synthesis elongation at the level of aminoacyl-tRNA binding to the 30S ribosome. Tetracycline passively diffuses through porin channels in the bacterial cell membrane. It also binds to the bacterial 50S ribosomal subunit which may alter the cytoplasmic membrane, causing intracellular components to leak from bacterial cells1. Mode of resistance is via loss of cell wall permeability.