Vinblastine sulfate salt

• 产品号: V1377
• CAS号: 143-67-9
• 分子式: C46H60N4O13S
• 分子量: 909.0526
• 纯 度: ≥96% (HPLC)

产品别名

• 标题: Vinblastine sulfate salt
• IUPAC标准名: sulfuric acid methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^4,^1^2.0^5,^1^0]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2(7),3,5,13-tetraene-10-carboxylate
• IUPAC传统名: sulfuric acid; vinblastine
• 别名: Vincaleukoblastine sulfate salt; VLB

产品登记号

• Beilstein号: 3659812
• MDL号: MFCD00082457
• EC号: 205-606-0
• PubChem SID: 24278771
• CAS号: 143-67-9

产品性质

• 纯度: ≥96% (HPLC)
• 相关基因信息: human ... TBCC(6903)
• 紫外吸收波长: A1mM/214 nm, ethanol 53.7
• 紫外吸收波长: A1mM/259 nm, ethanol 16.2
• 紫外吸收波长: A1mM/270 nm, 0.1 M phosphate buffer 14
• 外观: white powder
• 熔点: 267 °C (dec.)(lit.)
• 溶解度: H2O: soluble10 mg/mL
• 溶解度: DMSO: soluble50 mg/mL
• GHS警示词: Danger
• GHS危险声明: H302-H315-H318-H335
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• GHS警示性声明: P261-P280-P305 + P351 + P338
• 危险公开号: 22-37/38-41
• 安全公开号: 26-36/39
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing self-association in spiral aggregates in a reaction that appears to be regulated by the C-terminus of β-tubulin and is enhanced by GDP and GTP. Depolymerizes microtubules. Arrests the cell cycle in G2/M-phase by blocking mitotic spindle formation. Triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. Substrate of Pgp and CYP3A4.