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Bestatin hydrochloride_分子结构_CAS_65391-42-6)
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Bestatin hydrochloride

产品号 B8385 公司名称 Sigma Aldrich
CAS号 65391-42-6 公司网站 http://www.sigmaaldrich.com
分子式 C16H25ClN2O4 电 话 1-800-521-8956
分子量 344.8337 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 132429

产品价格信息

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产品别名

标题
Bestatin hydrochloride
IUPAC标准名
(2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid hydrochloride
IUPAC传统名
ubenimex hydrochloride
别名
N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine hydrochloride

产品登记号

MDL号 MFCD00058004
PubChem SID 24278278
Beilstein号 4628066
CAS号 65391-42-6

产品性质

纯度 ≥98% (HPLC)
产品质量级别 PREMIUM
个人保护装置 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
保存温度 -20°C
德国WGK号 3

产品详细信息

详细说明 (English)
Preparation Note
Solubility testing in water at 25 mg/ml yields a clear solution. Stock solutions at 1 mM are expected to be stable at least one month stored at -20 °C.
Biochem/physiol Actions
A metalloprotease inhibitor selective for aminopeptidase. Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase. It inhibits aminopeptidase B at 60 nM (using arginine-β-naphthylamide as substrate) and leucine aminopeptidase at 20 nM (leucine-β-naphthylamide as substrate). It showed no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or themolysin. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation.1

参考文献