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N-叔丁基-α-苯基硝酮_分子结构_CAS_3376-24-7)
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N-叔丁基-α-苯基硝酮

产品号 B7263 公司名称 Sigma Aldrich
CAS号 3376-24-7 公司网站 http://www.sigmaaldrich.com
分子式 C11H15NO 电 话 1-800-521-8956
分子量 177.2429 传 真
纯 度 ≥98% (GC) 电子邮件
保 存 Chembase数据库ID: 81904

产品价格信息

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产品别名

标题
N-tert-Butyl-α-phenylnitrone
IUPAC标准名
(Z)-N-tert-butyl-1-phenylmethenimine oxide
IUPAC传统名
(Z)-N-tert-butyl-1-phenylmethenimine oxide
别名
苯基·N-叔丁基硝酮
N-苯亚甲基-叔丁胺-N-氧化物
PBN

产品登记号

CAS号 3376-24-7
MDL号 MFCD00008799
EC号 222-168-6
Beilstein号 2044028
PubChem SID 24891981

产品性质

纯度 ≥98% (GC)
外观 white powder
熔点 73-74 °C(lit.)
溶解度 DMSO: soluble
个人保护装置 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS编号 TX1760000
保存温度 -20°C
德国WGK号 3

产品详细信息

详细说明 (简体中文)
包装
1, 5 g in glass bottle
Biochem/physiol Actions
N-tert-butyl-α-phenylnitrone (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy.1 The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100Å g).

参考文献