5-Aza-2′-deoxycytidine

• 产品号: A3656
• CAS号: 2353-33-5
• 分子式: C8H12N4O4
• 分子量: 228.20528
• 纯 度: ≥97%

产品别名

• 标题: 5-Aza-2′-deoxycytidine
• IUPAC标准名: 4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
• IUPAC传统名: decitabine
• 别名: 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; 2′-Deoxy-5-azacytidine; decitabine

产品登记号

• MDL号: MFCD00043011
• Beilstein号: 617982
• CAS号: 2353-33-5
• EC号: 219-089-4
• PubChem SID: 24890797

产品性质

• 纯度: ≥97%
• 溶解度: acetic acid: water (1:1): soluble50 mg/mL
• GHS警示词: Danger
• GHS危险声明: H302-H315-H319-H335-H341-H360
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• 危险公开号: 61-22-36/37/38-68
• RTECS编号: XZ3012000
• 安全公开号: 26-36/37
• 德国WGK号: 3
• GHS警示性声明: P201-P261-P281-P305 + P351 + P338-P308 + P313

产品详细信息

详细说明 (English)

Frequently Asked Questions
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General description
Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.
Biochem/physiol Actions
5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.