甲硝唑

• 产品号: M1547
• CAS号: 443-48-1
• 分子式: C6H9N3O3
• 分子量: 171.15396

产品别名

• 标题: Metronidazole
• IUPAC标准名: 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethan-1-ol
• IUPAC传统名: metronidazole
• 别名: 2-甲基-5-硝基咪唑-1-乙醇

产品登记号

• Beilstein号: 611683
• EC号: 207-136-1
• PubChem SID: 24896667
• CAS号: 443-48-1
• MDL号: MFCD00009750

产品性质

• 痕量阴离子: chloride (Cl-): ≤0.05%
• 痕量阴离子: sulfate (SO42-): ≤0.05%
• 痕量阳离子: Al: ≤0.0005%
• 痕量阳离子: Ca: ≤0.005%
• 痕量阳离子: Cu: ≤0.0005%
• 痕量阳离子: Fe: ≤0.0005%
• 痕量阳离子: K: ≤0.005%
• 痕量阳离子: Mg: ≤0.0005%
• 痕量阳离子: Na: ≤0.005%
• 痕量阳离子: Pb: ≤0.001%
• 痕量阳离子: Zn: ≤0.0005%
• 燃烧残渣: ≤0.1%
• 杂质: ≤0.0005% Phosphorus (P)
• 杂质: ≤0.1% Insoluble matter
• 熔点: 159-161 °C(lit.)
• 溶解度: acetic acid: soluble0.1 M, clear, faintly yellow
• GHS警示词: Warning
• GHS危险声明: H351
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P281
• 危险公开号: 40
• RTECS编号: NI5600000
• 安全公开号: 36/37
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Metronidazole is a nitroimidazole used to treat amebiasis, vaginitis, Trichomonas infections, giardiasis, anaerobic bacteria and treponemal infections. Metronidazole is used to study DNA damage and repair and has been found to induce the gene transfer agent VSH-1 in Brachyspira hyodysenteriae. It is commonly used for treatment of periodontitis and is used in bioavailability studies.
Biochem/physiol Actions
Metronidazole induces DNA strand breaks. Metronidazole is used to study DNA damage and repair and has been found to induce the gene transfer agent VSH-1 in Brachyspira hyodysenteriae.
Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. Reduced metronidazole covalently binds to DNA which disrupts its helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis. Bacterial cell death results.