黄曲霉素 B1 来源于黄曲霉

• 产品号: A6636
• CAS号: 1162-65-8
• 分子式: C17H12O6
• 分子量: 312.27358
• 纯 度: ≥98% (TLC and HPLC)

产品别名

• 标题: Aflatoxin B1 from Aspergillus flavus
• IUPAC标准名: (3S,7R)-11-methoxy-6,8,19-trioxapentacyclo[10.7.0.0^2,^9.0^3,^7.0^1^3,^1^7]nonadeca-1,4,9,11,13(17)-pentaene-16,18-dione
• IUPAC传统名: aflatoxin B1

产品登记号

• CAS号: 1162-65-8
• Beilstein号: 1269174
• EC号: 214-603-3
• MDL号: MFCD00869647
• PubChem SID: 24891116

产品性质

• 生物来源: from Aspergillus flavus
• 纯度: ≥98% (TLC and HPLC)
• 产品质量级别: PREMIUM
• GHS警示词: Danger
• GHS危险声明: H300-H310-H330-H350
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• 个人保护装置: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS警示性声明: P201-P260-P264-P280-P284-P301 + P310
• RID/ADR: UN 3462 6.1/PG 1
• 危险公开号: 45-46-26/27/28
• RTECS编号: GY1925000
• 安全公开号: 53-28-36/37-45
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 3462
• 联合国危险货物包装类别(PG): 1
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Warning
可能致癌。
Application
Aflatoxin B1 is a carcinogenic compound that induces transversion of G to T at codon 249 of the p53 tumor suppressor gene. Aflatoxin B1 may be used as an internal standard when testing for aflatoxin contamination in food products.
Biochem/physiol Actions
Hepatocarcinogen. Food contaminant produced by Aspergillus flavus, a common soil fungus. Aflatoxin is biotransformed to genotoxic intermediates by P450 Phase I enzymes, mainly CYP3A4 via aflatoxin B1 3-hydroxylation. Detoxification depends on Phase II enzymes, such as Glutathione S-Transferase and AFB(1)-aldehyde reductase (AFAR).
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A6636.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.