磺胺对甲氧嘧啶

• 产品号: S0383
• CAS号: 651-06-9
• 分子式: C11H12N4O3S
• 分子量: 280.30298

产品别名

• 标题: Sulfameter
• IUPAC标准名: 4-amino-N-(5-methoxypyrimidin-2-yl)benzene-1-sulfonamide
• IUPAC传统名: kiron
• 别名: N1-(5-甲氧基嘧啶-2-基)磺胺; 5-甲氧基磺胺嘧啶

产品登记号

• PubChem SID: 24899422
• CAS号: 651-06-9
• Beilstein号: 621130
• EC号: 211-480-8
• MDL号: MFCD00006067

产品性质

• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• RTECS编号: WP0525000
• 安全公开号: 26-36
• 保存温度: 2-8°C
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Application
Sulfameter is a sulfonamide antibiotic used as a leprostatic agent and to treat urinary tract infections1. It has been investigated as a potential therapy for chloroquine-resistant malaria during pregnancy2.
Biochem/physiol Actions
Sulfameter is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid3. Sulfameter is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.